Mycoplasma urealyticum is a type of mycoplasma that is widely colonized in the genitourinary tract. In clinical practice, most positive Mycoplasma urealyticum is found after the onset of urethritis in men and can be carried by healthy people without causing disease, and causes disease when the internal environment of the organism is changed or resistance is reduced. Mycoplasma urealyticum affects men in two ways: 1) it causes non-gonococcal urethritis in men; 2) it may affect sperm motility, thus affecting fertility, but its pathogenicity is not yet clear. Therefore, to determine the severity of Mycoplasma solium positivity in men, it should depend on the specific situation of the patient. Patients who are positive for Mycoplasma urealyticum without signs and symptoms can be considered carriers, and their condition is generally not serious enough to require treatment. However, if a diagnosis of Mycoplasma urealyticum urethritis is confirmed, it is recommended that their sexual partners be treated at the same time and that they take care to avoid unprotected sex during treatment. In addition, if a man has abnormal semen quality and has a need for fertility, both men and women should be treated at the same time.