In recent years, with the continuous development of medical technology and the further understanding of intrahepatic cholestasis, the surgical method of partial hepatectomy has been increasingly used for the treatment of intrahepatic cholestasis, but because partial hepatectomy is more invasive and has more complications, the scope of its surgical indications should be fully grasped. We have learned that left hepatic or left outer lobe of liver stones that are difficult to be removed, regional hepatic stones combined with bile duct stenosis, regional hepatic stones combined with hepatic lobe fibrosis and hepatic lobe atrophy, stone obstruction combined with chronic liver abscess above the obstruction or multiple liver abscesses can be treated by partial hepatectomy. The extent of partial hepatectomy has not yet been determined, because the extent of lobe fibrosis and atrophy due to stones is usually irregular, which changes the morphology of the liver and makes it difficult to identify regular lobectomy or segmental hepatectomy. We have learned that intermittent blocking of irregular one or more hepatic segments or lobectomies with the hepatoportal interval, checking the extent of resection while cutting, in order to achieve complete removal of stones and lobes that have lost function, and to preserve as much normal liver tissue as possible, reduce surgical trauma and complications, and facilitate the patient’s postoperative recovery. Partial hepatectomy for intrahepatic bile duct stones also has certain complications, but if the appropriate timing of surgery is chosen, avoiding surgery before the cholangitis has subsided, patients should apply antibiotics to control the infection before surgery, intraoperative bile is taken for bacterial culture and drug sensitivity test, and postoperative targeted application of antibiotics to prevent infection. The vessels and bile ducts in the liver section should be ligated one by one, and the liver section should be repeatedly flushed with saline, while the large omentum is used to tighten the liver section afterwards, which is very important to prevent bile leakage. Before closing the abdomen, the surgical field should be carefully flushed, and double cannula drainage should be disposed in the liver section, and negative pressure suction should be continued after the operation, which can effectively prevent intra-abdominal infection and is effective in preventing and controlling bile leakage. Pay attention to the perioperative treatment, try to correct hypoproteinemia and water-electrolyte disorders, control blood sugar, and pay attention to protect liver and kidney function before surgery. Postoperative strengthening of parenteral nutrition, the application of TPN nutrition solution treatment, etc., to promote the recovery of the patient’s body, enhance resistance, etc. are conducive to reducing postoperative complications, improve the effectiveness of surgical treatment. Intrahepatic bile duct stones are usually combined with bile duct stenosis. For patients with combined bile duct stenosis, it is difficult for patients to be cured by simple partial hepatic resection including the stenosis, so intraoperative resection should reveal the stenosed bile duct as much as possible according to the results of fiberoptic cholangioscopy combined with preoperative imaging data, and incision and plastic anastomosis should be performed. In our hospital, all patients with this combination and bile duct stenosis underwent incision and plastic anastomosis, large caliber bile duct jejunostomy Roux-y side anastomosis, and the anastomosis should be as large as possible with additional various measures to prevent reflux.