Condyloma acuminatum (CA), also known as genital warts or venereal warts, is an epidermodysplastic growth of the mucous membrane caused by the human papilloma virus (HPV) and is spread mainly through sexual contact. It is associated with genital, anal, and cervical cancer and is easily recurring. The general incubation period is 1-8 months, with an average of 3 months. The disease occurs in the coronal sulcus, foreskin, labia majora and minora, vaginal opening, perineum, perianal area, cervix, vagina, scrotum, and also in the oral cavity, rectum, and under the breast. The lesions start out as small, soft, light red warty papules, gradually increasing in size, and can be papules, keratotic plaques, papilla-like or cauliflower-like, corkscrew-like superfluous organisms, often with a tip at the root, and some even fuse into larger masses. They are prone to erosion, oozing and have a foul odor. The color ranges from pink to off-white. The warts are often small, flat papules in dry areas, and often papilla-like or cauliflower-like in moist areas. Patients are mostly asymptomatic, especially in women. Some patients may have itching, burning pain, painful intercourse and bleeding after intercourse, and women may have increased leucorrhea. The typical condyloma can be determined by the clinical experience of the specialist and the typical rash of the patient. Some atypical warts can be identified by different combinations of the following methods. The main point of differentiating condyloma acuminatum from several related conditions is that some physicians only pay attention to the skin damage in the genital area as shown by condyloma acuminatum, while ignoring that other diseases can also cause the same symptoms. The actual fact is that you can find a lot of people who are not able to get a good deal on a lot of things. Here you are taught how to self-identify condyloma acuminata with several related conditions: 1. Pseudomonal condyloma. The actual fact is that you can find a lot of people who are not able to get a good deal on a lot of things. The appearance may be due to physiological variation or increased irritation of the leucorrhoea caused by Candida albicans. It is generally not necessary to treat, to keep the local cleanliness, dryness, reduce the local stimulation. 2, penile pearl-like papules penile coronal groove along the edge of the glans, 1-3mm diameter white, skin color or light red pearl-like papules, smooth surface, do not fuse with each other, a row or several rows of arrangements, long time change is not significant, no conscious symptoms, no history of unclean sexual intercourse, white acetate test is not white. It can last for decades without change, and generally does not require treatment. 3, sebaceous gland ectopic occurs in the glans penis, labia mucosa, oral cavity, as yellow pinpoint and corn size papules, no obvious higher than the skin surface of the skin memory, no discomfort. It can last for several years without change, and generally does not require treatment. 4, Bowen-like papulosis damage is located in the male glans, penile stem, female perianal and labia, etc., as multiple small reddish-brown papules, 2-10mm in diameter, can be fused into plaques, mostly seen in sexually active people under 40 years old. Syphilis serologic tests and syphilis spirochetes are negative, and pathologic examination helps to differentiate. It is mainly due to human papillomavirus high-risk type 16 and 18 (HPV16 and 18) infection. The treatment is basically the same as for condyloma acuminata. 5, angiokeratoma Mostly seen in middle-aged men’s scrotum, a purple-red pinhead to soybean papule, the surface is mildly keratinized, the white acetate test negative. It is generally not necessary to treat, but also available freezing, laser or electrocautery treatment. 6, flat warts for the second phase of syphilis rash, often occurring in the perianal and vulva, performance for hypertrophic plaques, the surface flat and erosion, there can be dense particles in the form of papillae, cauliflower-shaped, broad base. There is a history of chancre and other syphilis rash damage, dark-field examination can detect syphilis spirochetes, and syphilis serology is positive. The treatment method according to syphilis. 7, infectious molluscum contagiosum. The first thing you need to do is to get a good idea of what you’re looking for. 8, folliculitis is mainly due to bacterial infection, in the hair many places, such as male mons pubis, scrotum, female mons pubis, the outer labia and perineum and around the anus, for follicular inflammatory papules, itchy and slightly painful, a few days after the self-receding and healing, not leaving a scar. Sometimes there are pus spots on the top of the papules, surrounded by redness and swelling, and hard nodules can be palpated at the base, which are painful and can exist singly or occur simultaneously. Most of the antibiotics are given orally and locally. 9, papular syphilis rash Papules are round, slightly elevated, red to crimson, 2-5mm in diameter or larger, infiltrated by touch, mostly without conscious symptoms. Circumscribed syphilis rash is commonly found on the pubic area, especially the penile shaft and scrotum, the rash is circumscribed, bowed or gyrate, the surface has scaly edges mildly elevated, composed of tiny flat papules, positive for syphilis seropositivity. Treatment according to syphilis. 10, seborrheic keratosis This disease is mostly seen in middle-aged and elderly people, mainly manifested as oval or irregular patches of vulva or papilloma-like projections, the surface covered with oily pale white scabs or dry and rough, and normal tissue boundary is clear, no conscious symptoms, generally do not need to deal with, but also available freezing, laser or electrocautery treatment, if necessary, surgical treatment. 11, warty xanthoma Prevalent in the oral cavity, female pubic, penis, scrotum, for yellowish warty damage. Generally, it does not need treatment, but can also be treated by freezing, laser or electrocautery. 12.Genital squamous cell carcinoma Most often seen in people over 40 years old, often on the basis of the original chronic skin lesions. Damage infiltration is obvious, hard and often forms ulcers. No history of impure sexual intercourse and histopathological examination can identify it. It should be treated surgically, and radiotherapy is required if necessary. The main treatment methods are summarized 1. 2.Local drug treatment can be used 0.5% pediculosis toxin (onychotoxin), 20% pediculosis lipid benzoin tincture, 5% 5-fluorouracil cream or 2-5% 5-fluorouracil solution, 80-90% trichloroacetic acid solution, 3% peptide butylamine cream, 2-8% colchicine solution, paterin solution. 3. Interferon can be injected locally or intramuscularly. It can also be injected intramuscularly with polymyxin, thymidine and BCG. 4, the latest photodynamic therapy is more effective, low recurrence rate, and can treat HPV virus subclinical latent infection lesions, to prevent recurrence.