Chronic hepatitis B virus carriers or hepatitis B patients are afraid to get married and have children because they are worried about their contagiousness, and some people are bouncing around from large and small liver clinics with the idea of “turning negative” and then getting married and having children, wasting time and money. So, can people with chronic hepatitis B virus infection (including chronic hepatitis B virus carriers or hepatitis B patients) get married? How can you have a healthy child? This article provides answers to the relevant questions. A, the issue of marriage regardless of the male or female, regardless of the level of virus in the blood is high or low, as long as the liver function is normal, no other contraindications to marriage, can get married, but in order to avoid infecting each other, it is best to get married after the other side of the hepatitis B vaccine and produce antibodies. The chances of the father transmitting HBV to the fetus before birth are negligible, although there can be hepatitis B virus in the semen, but not in the sperm, so hepatitis B is not inherited, even if the liver function is abnormal, it will not affect the sperm. But if you take the drug depends on the drug, such as the male partner during the application of antiviral drugs, it is best to take contraceptive measures, because the current antiviral drugs have not been found in human clinical evidence of adverse effects on germ cells, but in addition to tebivudine in animal experiments have been reported on the impact on the embryo, so the impact on germ cells can not be completely ruled out. 2, the woman is infected regardless of the amount of virus in the body is high or low, in the case of unmedicated as long as the liver function is normal for more than 6 months, and there are no other contraindications to pregnancy, and exclude the existence of factors that may have an impact on the development of the embryo, you can get pregnant normally. It is not advisable to be afraid of pregnancy for fear of transmitting the virus to the next generation. Similarly, insisting on pregnancy when the liver function is repeatedly abnormal is not good for the health of mother and child. It is advisable for patients with chronic hepatitis B to seek approval and advice from their doctors on avoiding mother-to-child transmission before planning a pregnancy. There are three ways of transmission from mother to child: 1) intrauterine transmission 2. during delivery, mainly when the newborn is infected during labor. 3. Transmission during close contact between mother and child in daily life after birth. The current measures to interrupt mother-to-child transmission are mainly for the latter two. If the mother is HBsAg and HBeAg positive, the method of interruption should be combined with active and passive immunization. Hepatitis B immunoglobulin is the key to interruption and should be injected as early as possible after birth for early protection, preferably within 12 hours after birth at a dose of 200 units, along with 10 μg of recombinant yeast or 20 μg of Chinese hamster oocyte hepatitis B vaccine at different sites, and the second and third doses of hepatitis B vaccine at 1 and 6 months of age, respectively; or one dose of hepatitis B immunization can be given within 12 hours after birth. The second dose of hepatitis B immunoglobulin can be administered within 12 hours of birth, followed by the second dose of hepatitis B immunoglobulin 1 month later, and a 10 μg recombinant yeast or 20 μg Chinese hamster oocyte hepatitis B vaccine at different sites, followed by the second and third doses of hepatitis B vaccine at 1 and 6 months intervals, respectively. One point to note is that when hepatitis B immunoglobulin and hepatitis B vaccine are administered simultaneously, they should be chosen to be injected on different sides of the rump so that local neutralization of the vaccine (antigen) and globulin (antibody) can be avoided. The combination of hepatitis B vaccine and hepatitis B immune globulin provides more than 90% protection for newborns of mothers with “major triplets”. A small percentage of infants of mothers with high levels of hepatitis B virus will still be infected with hepatitis B even with the combination of hepatitis B vaccine and anti-hepatitis B immune globulin. Failure of immunization for mother-to-child transmission is associated with a high viral load in the mother’s blood. When HBV DNA levels in the blood are high, even combined active and passive immunization cannot completely block its transmission from mother to child. Therefore, reducing the viral load in maternal blood is expected to reduce the incidence of intrauterine infection and immunization failure. It has been reported that a monthly injection of hepatitis B immunoglobulin in the last trimester of pregnancy can reduce maternal viral load and thus reduce mother-to-child transmission. It is now recommended that the mother begin taking nucleoside antiviral drugs in the second trimester (3 months before delivery) to reduce the level of virus in the blood at the time of delivery in order to reduce the likelihood of transmission. There are two types of drugs available, one is tebivudine, the only nucleoside class B drug currently available in China for pregnancy (not class A, which cannot be considered absolutely safe), and clinical data from small samples confirm its safety and effectiveness in preventing mother-to-child transmission, but large samples of clinical data are still needed to confirm this. Secondly, lamivudine, although it belongs to pregnancy class C, has been confirmed to be safe for use in pregnant women in clinical studies at home and abroad. It should be noted that the above-mentioned usage is not mentioned in the instructions of the above-mentioned drugs, so doctors should fully communicate with pregnant women and their relatives before application. Because of the high detection rate of HBV DNA in the blood, amniotic fluid, vaginal secretions and colostrum of mothers with hepatitis B virus, the mode of delivery and breastfeeding are of great concern to families and society. Theoretically, natural delivery may increase or decrease the chance of infection because the newborn can swallow the infectious mother’s secretions and blood when passing through the birth canal, and the amount of maternal blood infiltrating the baby is significantly higher during natural delivery than during cesarean delivery, but in practice, there is no difference in the immunization failure rate between different delivery methods after the newborn is blocked by the combination of hepatitis B immunoglobulin and hepatitis B vaccine. Although HBV DNA has been reported to be detected in breast milk, no difference in the rate of anti-HBs positivity in infants between feeding practices has been found. That is, there is no conclusive evidence that cesarean delivery and artificial feeding reduce the rate of immune blockade failure, and therefore maternal chronic HBV infection should not be an indication for cesarean delivery and artificial feeding when combined active and passive immunization is used. Hepatitis B virus is not a factor in determining the mode of delivery, and the mode of delivery should be decided by the obstetrician according to her own condition at the time of delivery. V. How to contact between parents and baby after birth to be safe Fathers or mothers who are carriers of hepatitis B virus should be careful that body fluids such as blood and saliva do not come into direct contact with the baby, other normal contact, such as kissing the face head and feet, etc.. In fact, even if the contact with bodily fluids, the chance of transmission is extremely low. But we can be more careful, of course, there is nothing to lose.