For thousands of years, the clinical application of Chinese medicine is mainly in the form of soup. Despite the rapid development of Chinese medicine preparations in recent times and the wide application of various new dosage forms, many patients still insist on “boiling medicine”, and even though decoction-free granules of Chinese medicines are very convenient nowadays, they still cannot replace “boiling medicine”. Even though decoction-free granules of Chinese medicine are very convenient nowadays, they still cannot replace “boiling medicine”, especially for the treatment of chronic diseases. Why is this the case? This is in addition to the soup to facilitate the clinical addition and subtraction of evidence-based treatment, but also closely related to the compounding of Chinese medicines, which is also the advantage of Chinese medicine. After the compounding of Chinese medicines, what changes have taken place between the medicines? What are the effects of these changes on the efficacy of the drugs? These are fundamental questions about the mechanism of Chinese medicine compounding. This issue has been a matter of interest to professionals in many disciplines at home and abroad, and in recent years there have been many reports of research in this area, but it still needs to be explored in depth. Synthesizing the researches in various aspects, there are several aspects of understanding as follows. 1, traditional Chinese medicine in the process of compounding, is likely to produce “qualitative” changes, mainly refers to changes in chemical composition. “Soup” is the traditional dosage form and the most commonly used form of traditional Chinese medicine, water is the main solvent medium, the temperature of the decoction is sufficient to increase the possibility and speed of reaction. Drugs in the processing of concoctions and preparations added to certain organic solvents (such as wine, vinegar, etc.), more likely to promote the chemical reaction, different solvents on the extraction and dissolution of active ingredients in traditional Chinese medicine is different, and these different components involved in the reaction system may produce a variety of different substances and changes. 2, Chinese medicines in the process of compounding and co-formulation, the performance of physical dissolution and adulteration, and its efficacy may be the accumulation of the amount of each single drug in the effective valence. Chinese medicine prescription prescription of the same kind of medicine, such as the attack of solid heat, with large Chengqi Tang, regulating stomach Chengqi Tang, the formula of rhubarb and manganese nitrate, from the laxative effect, rhubarb rhubarb rhubarb in the rhubarb (anthraquinones), for the stimulating laxative, can stimulate peristalsis to promote defecation; manganese nitrate that is, sodium sulfate, for the solvent laxative, can be in the intestinal lumen formation of high osmolality, suction intestinal lumen of the water. If you look at the chemical point of view, rhubarb and manganese nitrate, an organic material, an inorganic material, in the common agent, although it does not produce chemical changes, but its pharmacological effect is different from each other to complement each other’s strengths and weaknesses, each other must be used. 3, Chinese medicine with “seven feelings” theory summarizes the interaction of Chinese medicine with. The earliest surviving book of herbs, “Shennong’s Classic of the Materia Medica,” summarizes the basic conditions that may arise from the compounding of Chinese medicines as seven aspects, known as the “seven emotions” of the drug. It is still the principle that must be followed in the clinical use of Chinese medicine.