I. Definition – Couples who have not used any contraception and have had regular sex for 1 year without giving birth. II.History taking 1.To know the pregnancy, prenatal situation: whether exposure to drugs, medications, environmental and endocrine disruption. 2.To know whether there is cryptorchidism, inguinal hernia surgery, testicular torsion, bladder neck or pelvic surgery in childhood. 3.Learn about pubertal onset: precocious puberty, delayed development; testicular injury or torsion; sexual behavior and sexually transmitted diseases; bacterial and viral mumps. 4.Know whether adults are exposed to antidepressants, antihypertensive drugs, salicylates, furans, radiotherapy and other medical history. Physical examination: height, weight, arm length, development of testes, epididymis, vas deferens, spermatic veins and secondary sexual characteristics. Fourth, auxiliary examination 1, semen routine; prostate fluid routine, etc.; 2, color ultrasound; 3, hormone examination: FSH, LH, T, E2 and other sex hormone series; 4, trace elements: zinc, selenium, iron, copper, manganese, VitE, etc.; 5, vasovaginography; 6, MRI of pituitary; 7, chromosome staining; V. Treatment 1, to improve the body’s environmental factors, 2, to address the cause of the treatment, 3, empirical treatment 4, Chinese medicine, 5, assisted reproduction. Chinese herbal medicine; 5. Assisted reproductive technology