The danger of depression is “high morbidity, high recurrence and high disability”. More than 60% of depressed patients have had suicidal wishes or behaviors, and 15% of depressed patients eventually die by suicide. However, according to statistics, less than 10% of the existing depressed patients receive relevant medication. Depression has so far been associated by many people with not being able to think, and is treated as a mere thought problem, a sub-health, rather than as a disease. Modern medicine has proven that depression develops biography, as a result of a combination of somatic factors, neurodevelopmental and psychosocial factors. Family history; poor parenting in infancy and early childhood affecting neurodevelopment; sudden disasters and chronic stress can all be contributing causes of depression. It is widely accepted in the medical community that the development of depression is associated with reduced levels of a substance in the brain called 5-hydroxytryptamine. This is a substance associated with mood conveyance, and if levels are reduced can lead to low mood, and as a flip side, higher levels of 5-hydroxytryptamine have been shown to be associated with another mental illness, mania. ”High morbidity, high recurrence and high disability” is the summary of mental health experts for the danger of depressive disorders. Professor Yang Fu De, vice president of Beijing Huilongguan Hospital, said that depressed patients will fall into a “negative cognitive pattern” and are prone to self-blame and self-sin. Always think that they are making mistakes every day, can not do anything, always add trouble to others. In severe cases, they may also think that they live is a disaster for others. “Let’s say there is a patient who believes that he is responsible for all the car accidents that happen in society every day. This is a typical delusion of self-crime.” Such a mindset develops to a point where “the mood disturbance can go beyond the fear of death.” Suicide is the most serious consequence of depression. More than 60% of depressed patients have had suicidal wishes or behaviors, and 15% of depressed patients eventually die by suicide. The high rate of relapse is another dangerous aspect of depression. According to Zhou Dongfeng, professor at the Institute of Mental Health of Peking University and chairman of the Psychiatric Society of the Chinese Medical Association, the natural course of the first episode of depression is about six months to two years, and the risk of relapse is as high as 50% even if the patient is in remission without treatment, 70% for two episodes, and 90% for three episodes. Long-term follow-up studies have found that depression, if left untreated for a long time, will produce irreversible damage to the patient’s central nervous system, with significant deficits in cognitive function, making treatment more difficult, and resulting in so-called disability. Among the world’s top ten major diseases that disable or incapacitate people, five are mental illnesses, of which depression ranks first.