Effective treatment of major depression generally has the following methods: 1) medication treatment; 2) psychotherapy; and 3) physical therapy methods. Medication is commonly used for selective 5-hydroxytryptamine reuptake inhibitors, such as fluoxetine, paroxetine, fluvoxamine, citalopram, and drugs with a similar structure to citalopram, i.e., escitalopram. Dual-channel drugs such as duloxetine and venlafaxine can also be taken. Some newer antidepressants can also be taken, such as bupropion, vortioxetine, agomelatine, etc. At the same time, psychotherapy can be considered. Commonly used methods include cognitive-behavioral therapy, psychoanalytic therapy, Morita therapy, etc. All these psychotherapy methods require seeking the help of a counselor, or psychotherapist, establishing a very good relationship with the counselor, under the guidance of the psychotherapist for systematic rehabilitation, learning to grow and learn to overcome the problem of depression. Physical therapy methods especially for severely depressed patients, even those with negative thoughts, can consider electroconvulsive therapy methods. All the above methods are possible and must be actively treated under the guidance of a doctor.