[Condition introduction] At the end of July, a patient was admitted, so-and-so, male, suffering from liver cirrhosis for 20 years, with a long history of alcohol consumption (the onset of the disease has been stopped drinking), hepatitis B two-to-thirty suggests that the surface antibody, core antibody, e antibody is positive, the whole body was yellowish at the time of admission, the total bilirubin＞500umol/L, direct bilirubin is mainly elevated, and the outside hospital has been treated for more than 20 days, with the yellowing ace “He had been treated for more than 20 days in an outside hospital, and had been treated with Smytia, albumin and cephalosporin, but the jaundice did not subside. After treatment, the patient was admitted to the hospital for diagnosis, and several problems were considered: 1. Jaundice was mainly due to elevated direct bilirubin, but the imaging suggested that there was no dilatation of the common bile duct and the common hepatic duct, which indicated that it was not an extra-hepatic obstruction but an intra-hepatic obstruction, and it was considered to be an intra-hepatic cholestasis after excluding tumors. 2, From the liver function and the overall performance of the patient, hepatocellular destruction was relatively mild, so there was no hepatitis B virus activity. 3, Leukocytes were persistently elevated, and the possibility of intrahepatic bile duct infection was considered to exist.