Rheumatic disease patients’ blood routine may be abnormal, usually prone to lower red blood cells, hemoglobin, thrombocytopenia, white blood cell abnormalities, etc.; it can also cause abnormalities in blood sedimentation, C-reactive protein, and so on. Rheumatic diseases are a group of chronic diseases that involve bones and joints and their surrounding soft tissues (such as muscles, tendons, synovium, bursa, ligaments and cartilage) and other related tissues and organs, and are mostly related to autoimmune reactions. Rheumatic diseases often cause blood abnormalities, such as decreased red blood cells and hemoglobin, thrombocytopenia, and abnormal white blood cells. For example, active systemic lupus erythematosus may lead to a decrease in hemoglobin and a decrease in white blood cells and platelets; rheumatoid arthritis can be seen as a decrease in hemoglobin and an increase in platelet count, which is often related to the activity of the disease. In addition to routine blood tests, rheumatic diseases may also cause changes in indicators such as increased blood sedimentation rate and elevated C-reactive protein, which are generally closely related to the degree of disease activity. If rheumatic disease exists, it is recommended that the patient consult a doctor in time and follow the doctor’s instructions to standardize the diagnosis and treatment.