Glutathione reductase (abbreviated as GR) is a flavoprotein oxidoreductase enzyme whose main role is to participate in the body’s redox reactions and is mainly found in the liver, kidney, pancreas, heart and other organs. Elevated glutathione reductase has both pathological and physiological factors. I. Pathological factors 1, liver disease: glutathione reductase is most abundant in the human liver, when the body liver lesions, such as hepatitis, severe fatty liver, cirrhosis, liver cancer, etc., there will be high glutathione reductase; 2, biliary tract diseases: when the body biliary tract diseases such as biliary stones, cholecystitis, etc., because the bile can not be discharged, stagnation in the gallbladder or liver, and then affect the liver function. At this time, glutathione reductase will also appear high phenomenon. Second, physiological factors 1, physiological jaundice: some newborns will have physiological jaundice, because of jaundice will also cause glutathione reductase appear high short-term; 2, diet: some people after eating or drinking alcohol, will increase the redox reaction in the body, inducing glutathione reductase activity increased, there will be a brief glutathione reductase high; 3, stay up late and strenuous exercise: stay up late and strenuous exercise will both promote redox reaction in the body and cause high glutathione reductase; 4, drugs: when taking some drugs, there may be a situation of drug-related liver injury, which will cause high glutathione reductase. The high cysteine reductase alone is not specific and cannot confirm the diagnosis of the disease, it needs to be combined with other tests for comprehensive analysis and timely treatment.