Leukoaraiosis is a heterogeneous disease, i.e., each person with leukoaraiosis does not have exactly the same clinical manifestations, so it is not possible to generalize whether leukoaraiosis is a major disease. For some patients, it only affects the skin and mucous membranes and is not a major disease. But for a few patients, there will be some eye blood vessels, nervous system involvement, the condition is more critical, and sometimes even affect the life, then can be called a major disease. The clinical manifestations of leukemia itself are relatively complex, and some patients with mild disease tend to have only oral ulcers, vulvar ulcers, and skin lesions manifested as erythema nodosum, pseudofolliculitis, acne-like folliculitis, and superficial thrombophlebitis, etc., without serious organ involvement. Therefore, these patients only have basic clinical symptoms, and their conditions are often mild, with relatively good prognosis and relatively simple treatment, so they are only called minor diseases. For patients with organ involvement, there can be gastrointestinal involvement, serious perforation and bleeding of the gastrointestinal tract, and neurological involvement, such as hemiparesis and aphasia caused by brainstem injury, intracranial hypertension, spinal cord injury, and so on. When the vascular system is involved, it can cause hemangioma, vascular embolism, and even vascular rupture, which are more serious and can be called major diseases. But overall the morbidity rate of patients with organ involvement is relatively low, so there is no need to worry too much. Therefore, for patients with leukoaraiosis, early diagnosis and active treatment will lead to early recovery from the disease.