Leukoaraiosis, also known as oral-ocular-genital syndrome, is characterized clinically by recurrent episodes of fine vasculitis with damage to the mouth, eyes, genitals and skin, which can involve medium and large blood vessels as the disease progresses to a severe state, showing multi-system and multi-organ damage. The symptoms of leukoaraiosis are: 1. The incidence of oral ulcers is about 98%, mostly as the first symptom. Prevalent in the lips, tongue, gums, mucous membranes and other parts of the mouth. Ulcers can be single or multiple, 2-10mm in diameter or larger, round or irregular in shape, with clear boundaries. The ulcers are usually self-limiting and can heal on their own in about 1 to 2 weeks, mostly without scarring, but they are prone to recurrence, at least 3 times a year. 2. The incidence of genital ulcers is about 80%. Mostly seen in the external genitalia, around the anus, perineum and other places. The damage is deeper and involves a larger area than oral ulcers, but the number is smaller and the number of recurrent episodes is significantly less than that of oral ulcers; it is often accompanied by severe pain and heals more slowly. 3. The incidence of skin damage is about 60%-80%, with various types of lesions, including erythema nodosum-like lesions and folliculitis-like lesions. 4. About 40% of other systemic manifestations are accompanied by joint swelling and pain, and can also involve the digestive tract, peripheral and central nervous system, heart, kidney, lung, epididymis and bone marrow. The above symptoms should be seen by the rheumatology department as soon as possible, and regular treatment should be followed according to medical advice.