Because the clinical symptoms of leukoplakia are oral and vulvar ulcers and ophthalmia as the main manifestation, patients feel heavy symptoms, recurrent and painful, and there is a lack of effective clinical treatment. Therefore, many people will seek Chinese medicine treatment to achieve better results. The disease presents a long-term, slow, progressive exacerbation of attacks and relapses, extensions and remissions, therefore, TCM clinical treatment can be divided into three phases: acute active phase, intermediate recovery phase and clinical remission phase. The symptoms include ulceration of the oral mucosa and vulva, burning pain, thirst and thirst for drink or not much drink, often accompanied by restlessness, low-grade fever and other systemic symptoms, the pulse is slippery or string, the tongue is light red or dull red, the moss is thin yellow, this is the evidence of damp-heat internal aggregation, depression for a long time into fire, the use of guide Chi san plus rhizome, slippery stone, etc. to clear the heart and lower the fire, guide the heat and dampness from the urine and out. If the patient’s attack originates from the extreme of emotion and will, the liver meridian fire, then most of them are accompanied by heart annoyance and bitterness, swelling and pain in the ribs, etc., available Danjuania Xiao Yao San to dredge the liver and remove fire, clear heat and cool the blood; if there is high fever and thirst, constipation, abdominal distension and abdominal pain, the blood picture is obviously elevated, blood sedimentation, CRP sharply increased, this is the internal incandescence of evil heat. If the heat in the Qi part is prevalent, Bai Hu Tang combined with Xiao Cheng Qi Tang can be used to clear the Qi and remove heat, and clear the turbidity from the internal organs. 2.Intermediate recovery period: The symptoms include improvement of oral and/or vulvar ulcers, fever, constipation, abdominal distension and abdominal pain have basically disappeared, and the blood picture, blood sedimentation and CRP have started to decrease or basically returned to normal. However, the disease is a systemic widespread inflammatory lesion of small vessels. Therefore, the treatment at this stage should be to clear the residual evil, activate blood circulation and remove blood stasis. If the residual evil is heavy, with low fever that does not subside and irritability that does not resolve, or add Chai Hu and Liver Dispersion. 3 .Clinical remission period: In this period, clinical symptoms and signs basically disappear or disappear completely, and blood picture, blood sedimentation, CRP and other experimental examination indexes also return to normal. Patients with initial attacks or those without important organ involvement often do not have obvious manifestations of yin and yang qi and blood bias, so the principle of treatment in this period is to improve the body’s immune function, prolong the remission period and reduce recurrence, and can be taken orally for 1 to 2 years. If there is yin and yang, the disease should be treated with Zuo Gui Wan, Right Gui Wan, Qiju Dihuang Wan and Jin Kui Kidney Qi Wan according to the situation of yin and yang, and the medicine should be continued for 1 to 2 years. If the disease is accompanied by joint, skin, kidney, intestinal, or nervous system damage, or if there is serious involvement of organ function in the late stage of the disease, the corresponding preparations or prescriptions should be formulated according to the detailed diagnosis of the situation. 2, the disease in the application of Western medicine hormone or / immunosuppressant treatment, often due to the withdrawal of Western medicine and relapse, according to the application of Western medicine after the reaction and individual situation to nourish the Yin products with Western medicine treatment, in order to reduce the side effects of Western medicine and reduce relapse, generally available Ginseng Astragalus Dihuang Tang plus or minus. 3, the disease is a recurrent disease, in the stage of no important organ damage, the prognosis is generally good; if recurrent attacks, and the involvement of important functions or progressive aggravation, the prognosis is poor.