Some patients with leukoaraiosis may develop central nervous system damage at the same time, also known as neuroleukoaraiosis. In addition to the three main features of oral mucosal aphthous stomatitis, ocular uveitis and painful ulcers on the vulva, its clinical features often include paralysis, meningeal irritation signs, personality changes and other symptoms of neurological damage after a certain interval. According to the site of neural involvement and clinical manifestations, neuroleukopenia can be divided into the following categories: 1, brainstem type leukopenia clinical symptoms may include headache, dizziness, pseudobulbar palsy, respiratory disorders, epilepsy, ataxia, etc. 2, meningoencephalitis type leukoencephalopathy has signs of meningeal irritation, intracranial pressure, optic papilledema, hemiplegia, aphasia, impaired consciousness, mental abnormalities, etc. 3.Spinal cord type leukoencephalopathy has different degrees of paraplegia, urinary incontinence, weakness of both lower limbs, sensory impairment, etc. 4.Peripheral nerve type leukoaraiosis accounts for about 10% of the central lesions, and the performance is mild. There is only numbness and weakness of the extremities, peripheral type sensory disorder, etc. 5, cerebellar lesion type often manifests as cerebellar ataxia. 6. Cerebral nerve palsy type with spreading nerve and facial nerve involvement is common. Special examination: cranial magnetic resonance imaging (MRI) can detect abnormal foci in the central nervous system of patients, mainly in the brainstem, especially in the midbrain, and similar abnormal signal shadows can be found in the basal nucleus of the thalamus, cerebral hemisphere spinal cord and cerebellum, etc. Brainstem atrophy can be seen in the late stage. The treatment of neuroleukopenia, Western medicine does not yet have therapeutic drugs for the cause of the disease, in the acute stage is mainly given hormone therapy, combined with Chinese medicine evidence-based treatment will have a more accurate effect.