Although the cause of leukemia is unknown, studies have shown that the disease is mainly related to infection, genetics, environment and immunity, and the pathogenesis is mainly due to the disease-causing factors that stimulate the abnormal immune response of the genetically susceptible people, so it is not contagious. Pathogenesis has the following points: 1, infection factors: the disease may be associated with lentivirus, herpes simplex virus, EB virus, Helicobacter pylori and other infections; 2, genetic factors: there is a family, regional aggregation phenomenon, with the characteristics of certain genetic diseases; 3, environmental factors: may be associated with pesticides and copper-containing insecticides in the environment; 4, immune abnormalities: patients with a variety of antibody-positive serum can be seen. The clinical manifestations of leukemia are recurrent oral ulcers and genital ulcers, recurrent uveitis, retinal vasculitis, pseudofolliculitis, erythema multiforme, and involvement of other systems may include arthritis, aortic regurgitation, encephalitis, pulmonary embolism, nephrotic syndrome, epididymitis, and so on. The treatment of leukoaraiosis focuses on the different manifestations of the disease, including bed rest in the acute stage, prevention of recurrence in the interictal period, local treatment including symptomatic treatment of oral cavity and ophthalmitis, and systemic treatment including sardonyx, glucocorticosteroids, biologics and so on (for specific medication, please consult a specialist in a regular hospital).