Leukoaraiosis is a systemic immune system disease that can attack multiple organs of the body, including the mouth, skin, joints muscles, eyes, blood vessels, heart, lungs and nervous system, etc. It mainly manifests as recurrent oral and perineal ulcers, skin rashes, nodular erythema of the lower extremities, eye iritis, esophageal ulcers, small intestine or colon ulcers and joint swelling and pain, etc. It requires regular medication, including various immune-modulating drugs, and does not Without treatment, the prognosis is poor and in severe cases life-threatening. The early symptoms of the disease are mainly recurrent mouth ulcers, genital ulcers, inflammation of the eyes, joint pain, rashes, etc. General mouth ulcers can heal themselves with rest and eating more fruits and vegetables. If you find that mouth ulcers have been recurring, several times in a month should be beware. If you have recurrent mouth ulcers along with joint pain, eye inflammation and other symptoms, it is advisable to go to a hospital rheumatology department to check if you are suffering from the disease so as not to delay the treatment and cause irreparable damage.