There is no such thing as the three most feared signs of scleroderma; scleroderma is usually characterized by Raynaud’s phenomenon, joint pain, and skin damage. Scleroderma is a systemic disease of unknown cause, clinically characterized by limited or diffuse skin thickening and fibrosis, which can affect the heart, lungs and digestive tract and other organs. Clinical manifestations such as Raynaud’s phenomenon, joint pain and skin damage often occur. 1. Raynaud’s phenomenon: Raynaud’s phenomenon is often manifested as intermittent finger skin color changes, arterial spasm of the finger tips, accompanied by local numbness, pain, etc., which is usually relieved soon after warmth; it is the first symptom of scleroderma patients, and it can appear before other manifestations of the disease, such as arthritis and visceral involvement. 2. Joint pain: with the progression of scleroderma, fibrosis of tendons, fascia and skin around the joints can cause joint pain. 3. Skin damage: Typical skin lesions generally go through three periods: swelling period, some patients may have skin erythema, itching, etc.; sclerosis: the skin gradually becomes thick, hard, the skin is not easy to be lifted; atrophic period: the skin atrophies, becomes smooth and thin, tightly adhered to the subcutaneous surface of the bone, the joints can not straighten the flexion contracture, but also the skin ulcers can occur, and it is not easy to heal. Most scleroderma patients can also involve the heart and kidneys, leading to pericardial effusion and kidney failure and other diseases. It is recommended that patients with scleroderma seek medical treatment in a timely manner, and standardize the use of medication under the guidance of a doctor.