Depression is a common psychological disorder and should be treated immediately once diagnosed. Generally speaking, after a sufficient amount and course of treatment, 70% of depressed patients can achieve complete remission. One of the pathogenesis of depression is the reduction of neurotransmitter levels such as 5-hydroxytryptamine and norepinephrine in the brain. There are many kinds of antidepressants on the market, but they are summarized in the following four categories: 1. tricyclic antidepressants, doxepin, amitriptyline, which have greater side effects and have become the second-line drugs for depression; 2. selective 5-hydroxytryptamine reuptake inhibitors, such as fluoxetine, paroxetine, citalopram, which have little side effects, are effective and convenient to take, so these drugs 3. monoamine oxidase inhibitors, such as moclobemide; 4. other drugs, such as griseofulvin, mirtazapine, trazodone. Antidepressants are used in all types of depression, although different types of antidepressants and doses should be used selectively according to the type of depression. Next are twitch-free electroconvulsive therapy (ECT) and transcranial magnetic therapy (i.e., transcranial magnetic stimulation), etc. It is indicated for patients with severe negative thoughts, suicide attempts, other patients with major depression such as refusal to use food and behavioral retardation, and for those who are not effective with medication. Psychotherapy is helpful for all depressed patients. However, only supportive psychotherapy is not enough for patients with major depression, but must be accompanied by antidepressant treatment or twitch-free electroconvulsive therapy. Psychotherapy is most suitable for patients with mild depression in remission and chronic depression. Popular psychotherapeutic approaches include cognitive psychotherapy. Herbal therapy may be helpful in the management of patients with mild depression and depression in remission.