Syphilis, a chronic sexually transmitted disease caused by Spirochaete pallidum, is transmitted mainly through sexual contact, and can also be transmitted to the next generation through the placenta, resulting in congenital syphilis. Syphilis diagnosis needs to be confirmed by hematological testing, there are two main methods: 1, syphilis spirochete specific antibody test, can be used to detect whether the patient is infected with syphilis, this is also the most important way to detect syphilis; 2, non-syphilis spirochete antibody test, the most commonly used is the RPR detection test, can be used to detect whether syphilis is active, or syphilis after treatment is effective, etc.