With the recognition of the efficacy, minimally invasive and safety of radiofrequency ablation in the treatment of liver tumors, the application of radiofrequency ablation, a modern technique for liver tumor treatment, is becoming more and more popular. As we all know, there are three paths to perform RF ablation therapy: one is transdermal puncture path. It is to puncture the radiofrequency needle through the skin and liver into the liver tumor under the guidance of imaging equipment such as CT or ultrasound. The advantage of this path is that it is relatively simple to carry out, and the physicians who carry out this path are not limited, they can be surgeons, interventionalists or imaging physicians; the disadvantage is that there is a lack of intuitive judgment on the ablation efficacy, and it is easy to produce side damage to the perihepatic organs. The second is the laparoscopic route. It is suitable for subperitoneal tumors located in the perihepatic area, especially those closely related to the diaphragm, gastrointestinal tract and gallbladder, and is performed under direct vision with the help of laparoscopic technology. The advantage is that it can avoid side damage to important organs such as gastrointestinal, diaphragm, heart, gallbladder, etc., more accurate judgment of ablation scope, more intuitive judgment of efficacy, and better ablation efficacy; the disadvantage is that a surgeon is required to carry out the procedure under laparoscopy, and non-surgeons are limited to carry out the procedure. The third is the open route. It is to perform radiofrequency ablation in the open abdomen. The advantage is that the tumor surrounding tissues can be effectively separated to maximize the exposure of the tumor; the disadvantage is that the procedure is very traumatic and the postoperative recovery is slow. This route is now used sparingly. Through the above analysis, it is easy to see that the transdermal puncture route is suitable for small tumors in the liver; for subperitoneal tumors located in the periphery of the liver, because of the close relationship with the location of diaphragm, gastrointestine and gallbladder, when choosing the transdermal puncture route, it is easy to cause complications such as thermal injury or perforation of diaphragm, perforation of gastrointestine, perforation of gallbladder and pericardial tamponade, and it is appropriate to prefer the laparoscopic route. In addition, from the perspective of long-term outcome, the laparoscopic route is also preferred for subperitoneal tumors located in the periphery of the liver, because a large amount of data shows that the laparoscopic route can achieve a higher rate of complete ablation and long-term outcome compared with the percutaneous puncture route.