Central precocious puberty, also known as true precocious puberty, is due to the premature activation of the hypothalamic-pituitary-gonadal axis and the enhanced secretion of pulses of gonadotropin-releasing hormone. In addition to the development of secondary sexual characteristics, the child has ovarian or testicular development. Sexual development occurs in the same order as normal pubertal development, but at an earlier age. The causes of central precocious puberty in children include abnormalities of the hypothalamic-pituitary-gonadal axis, abnormalities of the central nervous system and other factors. 1. Abnormalities of the hypothalamic-pituitary-gonadal axis: This is due to a decrease in the sensitivity of the hypothalamus to the negative feedback of sex hormones and a premature increase in the secretion of gonadotropin-releasing hormone. 2. Abnormalities of the central nervous system, including: ① tumors or occupying lesions: hypothalamic malformation tumor, cysts, granulomas; ② infections of the central nervous system; ③ acquired injuries: traumatic injuries, postoperative period, radiotherapy or chemotherapy; ④ congenital developmental anomalies: hydrocephalus, optic septal insufficiency and so on. 3. Other diseases: central precocious puberty can occur in a few patients with untreated primary hypothyroidism. If your child has central precocious puberty, we suggest that you consult an endocrinologist immediately to avoid delaying your child’s condition.