The typical clinical manifestation of stage I syphilis on the tongue is also a hard chancre, which mostly occurs in people with specific sexual behavior. The hard chancre is a painless ulcer with a small amount of plasma discharge on the surface and is cartilage-like in hardness when touched, and is highly infectious. If stage II syphilis occurs in the oropharynx, tongue, or throat, it appears as one or more well-defined erythema, edema, and erosion, and a grayish-white membranous substance may be attached to the surface. It is recommended that after infection with syphilis, you should actively go to a regular hospital for syphilis treatment, with penicillin preferred. If you are allergic to penicillin, you can be treated with erythromycin or doxycycline, and after treatment, you need to be reviewed regularly. If the patient is positive for AIDS, the treatment will be based on neurosyphilis.