Many patients tend to ask such a question when they visit the doctor, “Doctor, I now have good blood sugar control, but this drug has been used for several years, should I change it? I’m afraid it will hurt the liver (kidney), the instructions written on the side effects of quite a lot of”, that fact is really so? Detailed look at the drug instructions commonly labeled: “caution in liver insufficiency”, “caution in renal insufficiency”, individual labeling “adverse reactions: rare transaminase elevation”. In fact, “use with caution in case of renal and hepatic insufficiency” means that the drug should be used with caution in case of renal and hepatic insufficiency, rather than that the drug is likely to injure the liver or kidney. Because most drugs need to be metabolized and excreted by the liver or kidneys, when there are problems with liver and kidney function, the continued use of the drug may cause abnormalities in the concentration of drugs in the blood, especially when using hypoglycemic drugs may induce hypoglycemia due to the increased concentration of the drug, therefore, when there are abnormalities in the liver and kidney function, you should consult your doctor to clarify whether you need to modify the treatment plan. Currently available hypoglycemic drugs have been marketed after large-scale clinical studies and have been proven to be very safe. The rare cases of elevated aminotransferases and creatinine are very rare, similar to drug allergies, which may be related to individual genetic constitution and are not generalizable. On the contrary, using good hypoglycemic drugs to control blood glucose and improve lipid metabolism is crucial for the prevention and treatment of fatty liver and diabetic nephropathy, one of the chronic complications of diabetes mellitus. Meanwhile, for the treatment of diabetes mellitus in combination with existing chronic kidney disease, good control of blood glucose is also the most basic measure. Therefore, the concern of injury to the liver and kidney is not necessary, in the view of the specialist doctor, the role of hypoglycemic drugs is precisely – liver and kidney protection!