Hyperbaric oxygen has obvious effect on improving the development quotient of children with brain injury, and the longer the course of treatment, the higher the efficiency, the possible reason is that hyperbaric oxygen increases the partial pressure of oxygen, improves the cerebral circulation, stabilizes the cell membrane, etc. on the damaged brain tissue to produce the following effects: improving the integrity of the blood-brain barrier; inhibiting the damage of free radicals to brain tissue; promoting the repair of damaged brain tissue and neurological function recovery; increasing the use of sugar by brain tissue; reducing apoptosis after brain cell injury; enhancing the expression of neurotrophic factors in the brain and reducing the level of plasma endothelin; helping to improve the state of wakefulness. Brain cell apoptosis after injury; enhance the expression of neurotrophic factors in the brain and reduce the level of plasma endothelin, etc. Increase the partial pressure of oxygen in the reticular activating system of the brainstem and other parts of the brain stem; and help to improve the state of wakefulness. The comprehensive intervention has synergistic effect on improving the clinical symptoms of brain injury. Some scholars believe that hyperbaric oxygen can promote the formation of oxygen free radicals and aggravate neonatal brain injury; hyperbaric oxygen can also cause cerebral vasoconstriction and reduce cerebral blood flow, which is not conducive to the recovery of brain cells, so it is proposed to apply hyperbaric oxygen for the treatment of neonatal brain injury, the safety and long-term efficacy of the treatment is debatable. In recent years, many clinical studies have proved that the therapeutic effect of hyperbaric oxygen on brain injury in high-risk infants is certain. Research on the mechanism of hyperbaric oxygen action found that hyperbaric oxygen can increase the blood oxygen concentration, improve the supply of oxygen to various organs and tissues, improve the metabolism of brain tissues, and promote the repair of brain injury; hyperbaric oxygen can make the vasoconstriction of the parts of the brain tissues where the oxygen supply is normal, and the cerebral blood flow is reduced, but it can make the cerebral blood vessels of the damaged parts dilate, increase the cerebral blood flow of ischemic area, and reduce the cerebral edema; and increase the partial pressure of oxygen in the parts of the brainstem reticular activating system and so on,. Thus, it can play a protective and repairing role for the brain in neonatal brain injury. The impact of early intervention on the prognosis of brain injury The first few years of life are a period of rapid development of the brain, intelligence, and social adaptability of the child, more than any other period of time, and good parenting stimulation before the age of 2 years, and especially during the first year of life, has an important impact on brain function and structure, as well as on biochemical aspects. Many studies have shown that the mature brain has a marked reversibility of its response to injury, and that early infant stimulation can lead to complete or partial functional recovery of neurological deficits caused by damage to brain structures. Infancy is a critical period for intellectual development, and early intervention promotes intellectual development. Through observation, we realize that the factors affecting the output of hyperbaric oxygen therapy are: ① Dosage selection: Hyperbaric oxygen therapy must choose the appropriate dosage, including pressure, oxygen concentration, oxygen inhalation time, and the duration of treatment, one of which is insufficient or excessive can affect the efficacy of the treatment. Auxiliary treatment: Hyperbaric oxygen and some drugs have a synergistic effect. ② Timing of treatment: Improving the hypoxia of brain tissue in the early stage of brain injury is the key to treating brain injury, but we should pay attention to the timing and method of hyperbaric oxygen therapy and the cooperation with other methods, and pay attention to the use of early, sufficient amount, and a long course of treatment. In order to achieve the ideal effect, screening means must be used to timely detect children with brain injury, strive for early diagnosis and early treatment, and timely control the further development of brain injury. Early intervention for high-risk children with brain injury can significantly reduce the occurrence of sequelae and improve the prognosis of high-risk children with brain injury. In conclusion, cerebrolysin, cerebrolysin, danshen and hyperbaric oxygen can play a protective role against brain injury by different mechanisms, and early intervention plays an important role in reducing the incidence of disability in children with high-risk brain injury. Brain injury in high-risk children leads to brain nerve cell damage, causing neurological dysfunction, and its main pathological changes are swelling of brain cells, cerebral metabolic disorders, service edema, and increased intracranial pressure. The longer the time of cerebral hypoxia, the more obvious the brain cell edema, and the more serious the dysfunction. The mechanism of hyperbaric oxygen therapy for neonatal brain injury in high-risk infants lies in the fact that oxygen inhalation under more than 1 atmospheric pressure can increase the amount of dissolved oxygen in arterial blood, improve the oxygen tension, promote the diffusion of oxygen from the blood to the tissues, alleviate the lack of oxygen in the brain tissue, and make the cerebral blood vessels dilated in the early stage of the disease contract, reduce cerebral blood flow, relieve cerebral edema, reduce intracranial pressure, and block a series of pathological processes in brain tissue caused by oxygen deprivation to promote the recovery of the damaged brain cells as soon as possible. Promote the recovery of damaged brain cells as soon as possible.