Patients with liver disease may not necessarily have symptoms if they have only mild liver damage, but if the liver damage is more serious, it can be manifested as digestive symptoms, liver discomfort, systemic manifestations, liver palm, spider nevus, ascites, hemorrhage, hepatic encephalopathy, etc. 1. digestive symptoms: generally manifested as loss of appetite, aversion to greasy food, abdominal distension, nausea, vomiting, etc. 2. liver discomfort: when liver damage occurs with liver enlargement, the liver envelope is stretched by The pain and discomfort in the liver area can be manifested by the pulling of the liver envelope. In patients with hepatocellular carcinoma, the liver gradually increases in size, and pain and discomfort in the liver area can also appear in the late stage; 3. Systemic manifestations: general discomfort, weakness and fatigue are the more common manifestations. If accompanied by jaundice, it is manifested as deepening of urine color and yellowing of eyes and skin. Patients with cholestatic jaundice are accompanied by itchy skin and white stools; 4. Liver palms and spider nevi: generally seen in patients with long-term chronic liver damage or cirrhosis. If chronic liver damage is not treated and the disease continues to progress, the liver’s function of inactivating estrogen decreases and dullness of the face, spider nevi and liver palms will appear. Spider nevi are often distributed on the face, chest, back or both upper limbs. When pressure is applied to the center of a spider nevus, its small outward radiating vascular network (pseudopod) subsides, and can reappear after pressure is removed. Hepatic palms appear as red spots or patches of dilated blood vessels between the small and large fissures of the palms of the hands, which become pale white after pressure is applied. Normal people occasionally have liver palms and spider nevi, so having liver palms and spider nevi is not a sign of liver disease; 5, ascites: chronic liver disease into the decompensated stage of cirrhosis or liver failure, due to portal hypertension, hypoproteinemia and other reasons can appear ascites, manifested as abdominal distension, urine less; 6, bleeding: severe liver damage, coagulation dysfunction, can be manifested as skin mucous membrane bruises, bruises, gum bleeding, etc.. Chronic liver disease into the decompensated cirrhosis, due to portal hypertension can cause esophagus – fundus varices, if eating rough, hard food, can cause venous rupture bleeding, manifested as vomiting blood, black stool; 7, hepatic encephalopathy: seen in patients with acute and chronic liver failure, decompensated cirrhosis, manifested as abnormal behavior, personality, confusion, decreased calculation power, serious cases can be coma. If patients have the above symptoms related to liver disease, they need to go to the hospital in time to determine the cause and take targeted treatment measures.