There are many causes of headache accompanied by nosebleeds. The more common causes are acute rhinitis, acute sinusitis, fungal sinusitis, and in some cases, nasal and sinus hemangioma and involute papilloma. Some patients are caused by sinus squamous carcinoma or nasopharyngeal carcinoma, and some patients are caused by leukemia, and there are some individual differences in the specific causes. After the onset of the disease, it is recommended to visit the ENT department, where routine blood tests, coagulation tests, and nasal endoscopy can be done to help determine the condition initially. For some patients with complex conditions, sinus CT and MRI of the head are also required. After the specific condition is clarified, targeted treatment can be carried out and regular review is needed to observe the effect.