The difference between geriatric depression and Alzheimer’s disease is mainly reflected in two aspects: mood and cognitive function. Cognitive function will also improve with the improvement of mood, so it is reversible and can be improved with systematic and standardized treatment. Alzheimer’s disease is a degenerative disease of the brain and an organic disease. The first symptom of Alzheimer’s disease is the decline of cognitive function, mainly memory loss, especially near-memory impairment, and the decline of calculation, comprehension, and judgment, and the gradual appearance of depression, anxiety, or emotional instability on the basis of this cognitive decline. The symptoms of Alzheimer’s disease are irreversible and the course of the disease is progressive.