Uric acid is the end product of purine metabolism and is mainly produced by the enzymatic breakdown of nucleic acids and other purine analogues from cellular metabolism and purines from food. Adult enzymatic serum (plasma) uric acid concentrations range from 150 to 416 μmol/L in men and 89 to 357 μmol/L in women, approaching those of men after menopause. If the patient had uric acid measured by chance at 650μmol/L and retested a month later down to 150μmol/L, it may be because the patient consumed food rich in high purine, such as animal liver, kidney, anchovy, etc. before the first uric acid test, because the uric acid production caused by food is proportional to the purine content in the food. In addition, alcohol can both increase the production and decrease the excretion of uric acid, thus increasing the blood uric acid concentration, so a patient’s history of alcohol consumption before testing blood uric acid can also cause an increase in blood uric acid concentration. In this case, the uric acid value is within the normal range because the cause of uric acid increase was avoided during the recheck. In this case the patient’s blood uric acid should be normal, only the first test was disturbed, in this case the patient is advised to try to avoid the disturbance and retest again. In addition, if the patient is a long-term uric acid level at 650μmol/L level, and after treatment it has dropped to 150μmol/L, it means that the patient’s treatment is effective, and he should continue to adhere to the treatment and monitor the blood uric acid concentration regularly. Therefore, the decrease of uric acid level from 650μmol/L to 150μmol/L in one month may be due to the above two reasons, and the corresponding screening and treatment should also be carried out according to the patient’s condition.