The metabolism of purines results in the formation of uric acid, which is excreted by the kidneys and liver of the body. Uric acid is produced in the liver by dietary intake and the breakdown of purine compounds in the body, and can lead to gout when there is excessive production or reduced excretion of uric acid. The general blood uric acid level > 420μmol/L is high, and 360μmol/L is normal, if this time also gout, consider caused by gout stone deposition, unreasonable application of uric acid-lowering drugs, etc. 1, gout stone deposition: normal uric acid gout will still attack, probably because uric acid will form urate crystals in the body, crystals precipitation deposited in the joints and surrounding soft tissues and other parts of the body. If you don’t dissolve it with medicine, it may cause inflammatory reactions in the joints, causing joint pain and gout symptoms, even if the patient’s uric acid is controlled in the normal range. Only when the uric acid crystals are dissolved to a certain extent and the uric acid remains stable for a long time, will gout be stable; 2. Irrational application of uric acid-lowering drugs: when applying drugs such as febuxostat tablets and benzbromarone tablets, it is necessary to start with a small dose and then gradually increase the dose according to the changes in blood uric acid levels. If a large amount of drugs are applied at the beginning, the uric acid level will drop rapidly, which may dissolve the uric acid crystals in the joints too fast and cause inflammatory lesions in the joints and symptoms such as redness, swelling, heat and pain.