Tests to rule out rheumatic immune diseases include blood tests, imaging tests, pathologic biopsy, etc. 1. Blood tests: In addition to routine tests, rheumatoid factor, blood sedimentation, anti-cyclic citrullinated polypeptide antibody, etc. can be checked when rheumatoid arthritis is considered; anti-nuclear antibody (including anti-nuclear antibody, anti-ds-DNA antibody, and anti-ENA antibody spectrum) can be checked when systemic lupus erythematosus is suspected; anti-neutrophil cytoplasmic antibody can be checked when vasculitis is suspected. 2. Imaging examination: for example, rheumatoid arthritis can improve the X-ray examination of the affected joints, which can clarify the progress of the disease, and it is also necessary to improve the chest radiograph to know whether there are rheumatoid nodules, interstitial pneumonia and other changes; in the case of suspected ankylosing spondylitis, it is necessary to improve the CT examination of the sacroiliac joints to make a clear diagnosis. 3. Pathological biopsy: for example, when SLE involves the kidney, kidney biopsy can be done to clarify the condition. Rheumatic diseases are more, each disease and specific conditions may be different selection of examination items, if suspected of suffering from rheumatic diseases, it is recommended that the patient in the regular hospital rheumatology and immunology department, under the guidance of the doctor to carry out investigations.