Primary hepatocellular carcinoma is a malignant tumor occurring from hepatocytes or bile duct epithelial cells, and a large part of them are primary hepatocellular carcinoma progressing from cirrhosis. In the late stage of cirrhosis, excessive proliferation of fibrous tissues during the repair process leads to hepatocarcinogenesis. Fourth, there are also some patients without cirrhotic basis, for example, aflatoxin can directly lead to the occurrence of hepatocellular carcinoma. In addition, bile duct cell carcinoma accounts for 10% of primary liver cancer, the etiology is not clear, and it is considered that it may be related to intra-biliary parasites or direct biliary contrast agents.