According to the clinical manifestations of chronic renal failure, it can be classified as “Guange”, “deficiency labor”, “retention of urine”, “drowning poison”, “kidney wind” and “edema” in Chinese medicine. “drowning toxicity”, “kidney wind”, “edema” and other categories. Chronic renal failure from azotemia to uremia stage, the disease is in the process of continuous development, so the TCM typology is not fixed, the early stage is mostly based on deficiency evidence, should be treated with deficiency, while the late stage because the metabolic toxins can not be cleared, thus manifesting as a complex symptom of mixed deficiency and reality, the standard reality becomes the main contradiction, so dynamic observation when clinical evidence. 1, dialectical treatment, support the righteousness and drain the turbidity 5 types of this evidence (1) spleen and kidney qi deficiency type treatment should be to strengthen the spleen and tonify the kidney, the formula is selected from the ginseng and white atractylodesis san combined with the right return pill plus reduction. Herbs: Ginseng, Poria, Atractylodes, Yam, 12g each, Lentil, 9g, Coix Seed, Sand, Cinnamon, 6g each, Eucommia, 9g, Fructus Lycii, Cornu Cervi Pantotrichum, 10g each. (2) Spleen and Kidney Yang Deficiency Type The treatment is to nourish the Spleen and Kidney, and the formula is Zhen Wu Tang, plus or minus. (3) Liver and Kidney Yin Deficiency Type The treatment is to nourish the Liver and Kidney. The formula is based on the combination of Six Bit Dihuang Pill and Er Zhi Wan, plus or minus. The remedy is: 12g of Radix Rehmanniae, 6g each of Cornu Cervi Pantotrichum, Yam, Zedoary, Poria, and Dampi, 9g of Fructus Maidenhair, and 12g each of Mercurialis. (4) Qi and Yin deficiency type The remedy is to benefit Qi and nourish Yin, and the formula is Ginseng and Astragalus, plus or minus Radix Ginseng and Astragalus, 12g each of Radix Rehmanniae, 24g of Radix Rehmanniae, 20g of Cornu Cervi Pantotrichum, and 9g each of Dampi, Poria, and Zedoary. (5) Yin and Yang deficiency type The remedy is to nourish both Yin and Yang, and the formula is Dihuang Drink or Ji Sheng Kidney Qi The formula should be selected from Dihuang Drinking Son or Jisheng Kidney Qi Pill, plus or minus: Shu Di 9g, Baji Tian 15g, Cornu Cervi Pantotrichum, Dendrobium 12g each, Cistanches 10g, Radix Aconiti 6g, Schisandrae 9g, Cinnamon 6g, Poria 12g, Medlar 10g, Licorice 3g. 2, concurrent evidence type 5 Dampness and turbidity: the treatment is to remove dampness and turbidity, the formula is to add or minus Wen Spleen Tang. Damp-heat evidence: treatment is to clear heat and dampness, using Huanglian Wenzhi Tang plus or minus. Water-Qi evidence: to promote Qi and promote water retention, using Spleen Drink plus or minus. Blood stasis: to invigorate blood circulation and resolve blood stasis, add and subtract with Tonic Yang Returning Five Tang. Cloudiness and toxicity: to remove cloudiness and remove toxicity, add and subtract from the formula. Or, on the basis of supporting the righteousness, according to the condition, add drugs for draining turbidity, resolving dampness, clearing heat, relieving water, resolving blood stasis, dispelling wind and quenching wind, etc. Most patients have a light red tongue, although they are thirsty and drink a lot, they have frequent nocturnal urination and long clear urine, which is different from the clinical manifestations of general yin deficiency. In addition to the symptoms of yin deficiency and qi deficiency, many patients have hot hands and feet, but cold fingers or toes, or cold body and hot hands and feet; the ambassador is dry first and then thin; there is excessive sweating and so on. These special atypical symptoms should be noted when defining the evidence. Chronic renal failure often causes the taste of ammonia in the mouth, nausea and vomiting, loss of appetite, stubborn diarrhea and other gastrointestinal symptoms, especially nausea and vomiting, so that the patient can not eat into the medicine, can make the condition worse. Therefore it must be controlled as soon as possible. Nausea and vomiting are caused by deficiency of spleen and kidney, water and dampness are not transformed and brewed into dampness and toxicity, and dampness and toxicity are contained within and damage the spleen and stomach, resulting in loss of elevation. If the tongue is white and greasy, the treatment should be warming and lowering the rebellion, with the formula of Xiao Han Xia plus Fu Ling Tang; if the tongue is yellow and greasy, it is dampness and toxicity into heat, the treatment should be bitter and pungent together, lifting and lifting, with the formula of Su Ye Huang Lian Tang, both should be taken in small amounts for many times, frequently sip, can make the vomiting stop quickly. If the stubborn appetite loss, or even anorexia, is due to damage of spleen and kidney yang qi, without the ability to digest the grain, it is appropriate to invigorate the spleen and stomach yang qi, can be warming and strengthening the spleen, with Xiang Sha Ping Stomach San or Xiang Sha Six Jun Zi Tang; can also ascend Yang and dry dampness, with the addition and subtraction of Qiang Wu De-Dampness Tang; if dampness and toxicity turn into heat, blocking the qi, it is appropriate to clear and open the drainage, with Huang Lian Wen Biao Tang. In case of stubborn diarrhea, which is another manifestation of the damage to the ascending and descending functions of the spleen and stomach, it can be treated by warming the middle and fixing the astringency, using Li Zhong He Tao Hua Tang, or Ginseng and Shen Si Shen Tang; in case of heat, it is also advisable to use both cold and heat, such as treating with Lian Li Tang with added flavor, which can achieve good results. In recent years, there are many reports of clinical use of rhubarb to reduce nitrogen in the blood, but after stopping the application, nitrogen in the blood can rise again, long-term application can aggravate the positive deficiency, in order to prevent rhubarb bitter cold injury to the spleen, more intestinal administration, can get good results.