In clinical application, it is often said that as long as the pentraxin reuptake inhibitors (of course, the “five golden flowers”), namely fluoxetine, paroxetine, fluvoxamine, sertraline, citalopram (and levocitalopram) are the same, there is no difference, is it really so? In fact, in my clinical work, I found that these drugs, in addition to the difference in the dose of each drug, they often respond to different individuals, the clinical efficacy and side effects are also different. For example, in the treatment of depression or obsessive-compulsive disorder, the first 1-2 days of fluoxetine showed obvious side effects: chest congestion, dizziness, nausea… After switching to citalopram, that is, using the same dose, there were no side effects at all and the treatment was successfully completed, and sometimes, vice versa, there were occasional side effects with citalopram as well. When treating with paroxetine, although this drug works quickly, the first dose often needs to be reduced, starting with 10 mg per day and gradually increasing the dose, and if there are still unpleasant side effects, a little Dextran or alprazolam can be added, which can not only increase the efficacy, but also make many side effects disappear. I have found that with the addition of Dexedrine, I can receive more significant results without that high dose. Sometimes, paroxetine can cause patients to develop pharmacogenic limb tremor, which is an extra-F reaction, with hand tremor being more common, and can be reduced or eliminated with the addition of a little Antan or Alprazolam. However, with fluoxetine, the above symptoms are less common. The appearance of adverse symptoms varies not only from drug to drug, but also from person to person. When I shared my opinion with my colleagues in the industry, they shared the same feeling. Some pharmacological studies tell us that the various selective pentraxin reuptake inhibitors (SSRIs) are very different from each other; in fact, they have effects on other neurotransmitter systems as well, and different SSRIs have different affinities for different transmitter receptors and inhibit the reuptake of different transmitters to different degrees. Each SSRI has a unique structure and there are significant differences in drug interactions and pharmacokinetics. In clinical applications, it is often found that some depressed patients who are ineffectively treated with one SSRI adequately will experience better outcomes if they are switched to another SSRI. Ancient Chinese medicine practitioners had no knowledge of pharmacokinetics, but paid great attention to distinguishing the differences in medication, not only the differences of individuals, but also the differences of time, season, climate and even region of medication, which cannot be said to be brilliant. In the past, Chinese and Western doctors were not united and attacked each other. Some Chinese doctors said that Western doctors were mechanical and stereotypical in their use of medicine, but I do not advocate attacking each other. Therefore, I would like to advise individual Western doctors to think more about the different characteristics of different drugs and individual differences of people when using drugs, and to think more about more ways for patients when the efficacy is not satisfactory, instead of sticking to one method or blindly increasing the amount of drugs.