Lead poisoning is mainly treated with chelating agents for lead expulsion, commonly used are calcium sodium edetate, disodium dimercaptobutyrate, dimercaptosuccinic acid and so on. After lead poisoning, the use of chelating agent can make it form stable and soluble metal chelates with the lead in the body and excrete it out of the body, so as to achieve the therapeutic purpose. Commonly used drugs for lead expulsion treatment include calcium sodium edetate, disodium dithiobutyrate, dimercaptosuccinic acid and so on. Sodium calcium edetate is the preferred drug. In addition, those who have abdominal colic after lead poisoning can use calcium gluconate intravenous drip or atropine, scopolamine for intramuscular injection, etc. as appropriate. During the course of the disease, attention should be paid to the monitoring of the condition and the maintenance of water-electrolyte balance. If lead poisoning is suspected, it is recommended to consult a doctor as soon as possible and follow the doctor’s instructions for standardized treatment after a clear diagnosis. The use of drugs must follow the doctor’s instructions, not blindly use their own drugs, so as not to cause adverse consequences.