Acute organophosphorus pesticide poisoning is a common type of poisoning, accounting for about 20% to 50% of poisoning cases. Acute organophosphorus pesticide poisoning refers to the acute poisoning symptoms after eating, inhaling or contacting a large amount of organophosphorus pesticides within a short period of time, which mainly manifests itself in the exhalation of garlic-flavored gases, profuse sweating, salivation (drooling), pinpoint narrowing of the pupils, increase in the secretion of the windpipe, and the emergence of consciousness disorders in the severe cases. Its pathogenesis is that after the organophosphorus enters the body, it combines with acetylcholinesterase, which makes acetylcholine can’t be decomposed, and more and more acetylcholine gathers in the neural connector parts, which triggers the symptoms of poisoning, and it is necessary to remove the poison as soon as possible and give the treatment of detoxification at this moment. For the poisoned patients, the first thing to do is to remove the poison, such as inducing vomiting or gastric lavage if it enters the digestive tract, take away the polluted environment if it is inhaled from the skin and mucous membranes, take off the polluted clothes, and wash the skin at the same time, etc. Secondly, immediately give sufficient amount of cholinergic enzyme reenactment agent, cholinergic receptor blocking agent and other antidote, and actively carry out the symptomatic treatment. For acute organophosphorus pesticide poisoning focus on active and effective prevention, such as wearing a mask when spraying, wearing protective clothing, etc., must not be negligent, so as not to affect health.