Pathological changes such as cortical gliosis, infarction and calcification, subcortical vacuolization, and abnormal enlargement of large cerebral veins and connection with many fine arteries. Brain injury occurs mainly by mechanisms such as arterial blood theft, cerebral ischemia secondary to heart failure, hemorrhagic infarction, lesion compression and surgical trauma. The diagnosis of cortical gliosis depends mainly on the age of onset and clinical manifestations, but radiological examination is required to confirm the diagnosis. The presence of intractable heart failure with intracranial vascular murmur in newborns; hydrocephalus in infants should be considered as a possibility of this disease. For those who can hear intracranial vascular murmur or present with subarachnoid hemorrhage, the diagnosis can be basically confirmed. The diagnosis can be further confirmed by MRI, brain Doppler ultrasound, solid sensory and compound sensory examination. MRI MRI, also known as magnetic resonance imaging, uses the principle of nuclear magnetic resonance to detect the electromagnetic waves emitted through an applied gradient magnetic field, which can be used to map the internal structure of an object. 2.Brain Doppler ultrasound is a method of examining the brain through brain Doppler ultrasound. Transcranial color Doppler imaging is performed through the temporal, occipital, and orbital windows to detect cerebral arteries, and is used to diagnose and classify the cause of cerebrovascular diseases based on the flow velocity, frequency width, abnormal flow direction, or abnormal audio of intracranial vessels. 3.Solid perception Solid perception (stereognosis) is a test of the ability of the hand to recognize the size, shape and nature of solid objects. 4.Compound sensory examination Compound sensory examination includes skin localization sensory examination, two-point discrimination sensory examination, graphic sensory examination and solid sensory examination. These sensations are the result of brain synthesis, analysis and judgment, so they are also called cortical sensations.