Indirect bilirubin is also known as non-conjugated bilirubin. When indirect bilirubin is elevated, it is important to clarify whether hemolytic jaundice, hepatocellular jaundice, and hemolytic diseases, neonatal jaundice, hepatitis, cirrhosis, liver cancer, or as a result of blood transfusion errors. Indirect bilirubin is eventually taken up by hepatocytes after it enters the liver with the bloodstream. When there is an increase of indirect bilirubin in the serum, it is important to consider whether there is any of the above diseases. Increased serum total bilirubin with significantly elevated indirect bilirubin suggests hemolytic jaundice, which causes the patient’s skin mucous membranes to appear light lemon in color, not accompanied by skin itching. When there is acute hemolysis, the patient will have loss of appetite, fatigue, low fever, vomiting, nausea, back pain, and varying degrees of anemia and hemoglobinuria, and in severe cases, acute renal failure. When total bilirubin, direct bilirubin and indirect bilirubin are all elevated, hepatocellular jaundice is caused by various diseases that cause severe damage to liver cells, such as viral hepatitis and liver cirrhosis. It causes a yellowish color of the skin with varying degrees of itching. Patients with elevated indirect bilirubin should first determine the cause of the elevated indirect bilirubin, paying special attention to liver diseases and blood diseases, and in some cases, to elevated indirect bilirubin caused by diseases such as cirrhosis and liver cancer.