Lymphoma is a malignant tumor originating from lymph nodes or lymphatic tissue, and is one of the ten most common malignant tumors in China, with varying degrees of malignancy, and can occur at any age. The main clinical manifestations are lymph node enlargement, as well as recurrent fever, itchy skin, cough, chest tightness, abdominal distension and abdominal pain. The pathological staging can be divided into two major categories: Hodgkin’s lymphoma and non-Hodgkin’s lymphoma. Hodgkin’s lymphoma is mostly seen in young and middle-aged people, and the first symptom is often painless enlargement of lymph nodes in the neck or supraclavicular region (60%-80% of cases), more on the left than on the right. This is followed by enlargement of axillary lymph nodes and deep lymph nodes. Most non-Hodgkin’s lymphomas also have painless neck and supraclavicular lymph node enlargement as the earliest manifestation, but generally develop rapidly and are prone to distant spread, with involvement of the gastrointestinal tract, bone marrow and central nervous system, and manifestation of corresponding organ involvement. In order to diagnose lymphoma, patients can undergo routine blood tests, serum immunoglobulin tests, routine urine tests, cellular immune tests, frontal and lateral chest x-rays and lymphography of both lower extremities, etc. However, these are all auxiliary tests, while the most important is to perform biopsy of lymph nodes. When painless lymph node enlargement is found on the neck or clavicle, a small incision is made on the surface of the skin, and the lymph nodes are removed and made into pathological sections for observation under a microscope to make a clear diagnosis. This procedure is minimally invasive, can be done under local anesthesia, and is easily accepted by the patient.