Recurrent stomach pains in children with swollen lymph nodes are usually considered to be caused by mesenteric lymphadenitis, which is often associated with respiratory or intestinal infections. However, some children may also have other illnesses, and parents need to take their children to the doctor to determine the cause and choose an appropriate treatment plan. The pain is usually vague, dull, or distended in nature, and is rarely associated with abdominal muscle tension and rebound pain. An elevated white blood cell count will be found during a peripheral blood test. In addition, diseases such as tsutsugamushi, infectious mononucleosis, and acute lymphoblastic leukemia can also cause swollen lymph nodes and recurrent stomach pain. The first step in treatment is to actively identify the cause of the disease and provide appropriate medication or surgery for the primary cause. For example, amoxicillin, cefixime and other antibiotics can be used for antibacterial treatment of mesenteric lymphadenitis, and ibuprofen or acetaminophen can be used for antipyretic and analgesic treatment; doxycycline and azithromycin can be used for antibacterial treatment of swollen lymph nodes and recurrent stomach pain caused by scrub typhus. If it is caused by infectious mononucleosis, if there is fever, active antipyretic and antiviral treatment is needed if necessary; if it is caused by acute lymph node cell leukemia, the main treatment is systemic chemotherapy. In addition, attention needs to be paid to the treatment of the primary disease, and close follow-up is required until it is cured. Hormone therapy is generally not recommended because glucocorticoids may affect the pathological results of lymph nodes, and the application of antibiotics should be considered only when infection is suspected. In addition, more attention should be paid to keeping children warm and developing good hygiene habits to avoid bacterial and viral invasion.