Depression has a high recurrence rate, with a lifetime risk of recurrence approaching 90 percent. The WHO Expert Advisory Group’s recommendations are: preventive medication should be given for at least 6 months after the first depressive episode is cured; preventive medication should be given for 3 years after the second episode is cured; and lifelong medication should be considered when a third relapse occurs. However, in clinical work, it should be considered according to the severity of the patient’s condition, work situation, and response to medication, but all of them should be put in the first place. If a depressive episode is accompanied by significant suicidal tendencies, a longer period of treatment should be considered. This should be given great attention by the majority of patients and their families!