1.Surgical resection: including hepatectomy (minimally invasive, laparoscopic resection of hepatocellular carcinoma) and liver transplantation. Early surgical resection is still the traditional and most effective treatment method that is not clinically useful at present. Surgical resection of small hepatocellular carcinoma and liver transplantation have similar results, and the 5-year survival rate after surgery is high, with a survival rate of about 80%. After radical resection, the 5-year survival rate of recurrent hepatocellular carcinoma can also reach about 60% after re-excision. 2.Surgical treatment for unresectable hepatocellular carcinoma: according to the situation, percutaneous transhepatic hepatic artery embolization chemotherapy (TACE), radiofrequency ablation (RFA) under ultrasound or CT positioning, image positioning or intraoperative argon helium knife cryoablation, image positioning or intraoperative anhydrous ethanol injection can be used. TACE can control the tumor development and shrink the tumor, which can prolong the survival time of patients. For larger unresectable tumors, RFA or Ar-He knife ablation is similar to TACE, but for single or multiple tumors less than 3cm, local ablation is effective and reliable. 3. Chemotherapy: systemic chemotherapy, mostly administered intravenously; intraoperative portal vein and/or hepatic artery chemotherapy pump placement and regular chemotherapy are helpful in reducing tumor recurrence. However, in general, chemotherapy alone has many side effects and the efficacy is not good. 4.Radiation therapy: In recent years, our department has carried out ultrasound-guided radioactive particle transfer and intraoperative particle placement for liver cancer, which can control tumor development, shrink tumor and reduce tumor recurrence, and has achieved good clinical effect. Although radiotherapy alone for liver cancer has certain curative effect on advanced liver cancer, but in general, the curative effect is not good. 6.Immunotherapy: commonly used are BCG vaccine, autologous or allogeneic tumor vaccine, immune ribonucleic acid, transfer factor, interferon and interleukin. However, after the application alone, but the efficacy is not good, need to be combined with other treatment methods to celebrate the use. 7.Therapeutic Chinese medicine is often applied in combination with other therapies to improve the body’s resistance to the disease and to improve the body’s ability to cope with the disease. In order to improve the body’s resistance to disease, improve the general condition and symptoms, and reduce the adverse effects of chemotherapy and radiotherapy, etc. 8.Molecular targeting therapy. For advanced hepatocellular carcinoma, the targeted therapy agent Sorafenib can be applied. It can prolong the life of patients.