At present, liver biopsy is still the most reliable method to diagnose liver fibrosis, however, as an invasive test method, it has potential complications, is not easily accepted by patients, and is inconvenient for routine follow-up and dynamic observation, so its clinical application is limited. In recent years, it has gradually become a trend to establish a noninvasive diagnostic model to determine the degree of liver fibrosis in chronic liver disease by combining several serological indicators. Bonacini’s Cirrhosis Discriminant Score (CDS) is a noninvasive diagnostic model proposed by Bonacini et al. for diagnosing the degree of liver fibrosis in chronic hepatitis C. In this study, this model was applied to chronic hepatitis B in China to verify its clinical value. DATA AND METHODS Study population One hundred and seventy-two patients with chronic hepatitis B admitted to the Department of Infectious Diseases of the People’s Hospital of Liuzhou, Guangxi, between June 2006 and March 2008, were diagnosed in accordance with the Viral Hepatitis Prevention and Control Program of 2000. Patients were positive for hepatitis B surface antigen (HBsAg) and hepatitis B virus (HBVDNA) for at least 6 months prior to enrollment, aged between 15 and 68 years, with no history of antiviral and anti-liver fibrosis drug therapy, and combined hepatitis A, C, D, and E virus infection was excluded. All patients underwent liver histopathological examination and serum was collected for relevant index tests. Clinical, blood and biochemical parameters were collected and recorded on the day of the liver biopsy or the day before. Laboratory tests The results of liver function [glutamic aminotransferase (ALT) and glutamic oxalacetic aminotransferase (AST), blood routine [platelets (PLT)] and coagulation function [international normalized ratio of prothrombin time (INR)] were obtained from routine clinical tests at the Department of Laboratory Medicine, Guangxi Liuzhou People’s Hospital. Histological examination After routine preoperative laboratory tests, if there were no contraindications, liver aspiration biopsy was performed with the patient’s signed informed consent for liver aspiration biopsy. Liver puncture was performed under ultrasound Doppler localization guidance, and conventional rapid 1-second aspiration biopsy was performed with a 19G disposable liver puncture needle or a common liver puncture needle, requiring liver tissue of 1.5 cm or more in length and 10% formaldehyde fixation. Two pathologists read the films blindly. Liver fibrosis was divided into five stages, namely SO: no fibrosis; S1: expanded fibrosis in the confluent area, limited perisinusoidal and intralobular fibrosis; S2: fibrosis around the confluent area, formation of fibrous septa, preservation of lobular structure; S3: fibrous septa with lobular structural disorder, no cirrhosis; S4: early cirrhosis. The films were read independently by 2 pathologists blinded, and repeated readings were performed to reach consensus in case of inconsistent diagnosis.