Weakness is generally a sign of malaise or extreme weakness, and often occurs in the developmental or late stages of liver disease. There are many types of liver diseases, all of which can be accompanied by symptoms of malaise, mainly related to malnutrition caused by factors such as reduced liver function, digestive and absorption disorders, and the following conditions are common: 1. Viral hepatitis: fever, chills, nausea and other symptoms dominate in the early stage of hepatitis A and E onset, followed by anorexia, malaise and skin-sclera jaundice, while the above symptoms can be relieved 3-5 days after the appearance of jaundice. In pregnant women and elderly people with hepatitis E, symptoms such as extreme malaise may occur when severe hepatitis and liver failure develop. Chronic hepatitis is also often accompanied by non-specific symptoms such as malaise and abdominal distension; 2. Alcoholic liver disease: alcoholic fatty liver can be asymptomatic, or mild malaise, lack of appetite and other symptoms can occur, and significant general malaise, malaise, pain in the liver area and other symptoms can occur after a short period of heavy alcohol consumption; 3. Autoimmune liver disease: it occurs in women around 30-50 years old, and can also occur in men, and mild patients can be asymptomatic, but the disease progressive stage can appear weakness, abdominal distension, jaundice and other symptoms; 4, cirrhosis: the early stage of cirrhosis has no obvious symptoms or mild symptoms, manifested as weakness, indigestion, diarrhea and other symptoms, which can be triggered by factors such as exertion, mental tension, etc., and relieved after rest or taking drugs to help digestion. While the liver is severely damaged, entering the decompensated stage can cause digestive malabsorption due to liver decompensation, and symptoms such as wasting, weakness, abdominal distension, mental discomfort, etc.; 5. Primary hepatocellular carcinoma: lack of typical symptoms in the early stage, usually it has already entered the middle and late stage when obvious symptoms appear, often developed on the basis of cirrhosis, pain in the liver area is the most common symptom, followed by symptoms such as progressive enlargement of liver, obstructive jaundice, while Systemic symptoms can be manifested as progressive wasting, malaise, fever, malnutrition, etc. Therefore, malaise is not specific; 6. Acute liver failure: acute onset, grade 2 or higher hepatic encephalopathy within 2 weeks, accompanied by systemic symptoms such as extreme malaise, marked anorexia, abdominal distension, nausea, etc., as well as progressively increasing jaundice, progressively shrinking liver and obvious bleeding tendency in a short period of time. If patients have unexplained weakness, it is recommended to seek medical attention, diagnosis and treatment in a timely manner to avoid delaying the disease and causing serious consequences.