Diarrhea is one of the adverse reactions of metformin, and metformin may also cause nausea, vomiting, abdominal pain, bloating, indigestion and other digestive discomfort, which are relatively common adverse reactions of metformin. It is recommended that if patients experience diarrhea when taking metformin, they can suspend the medication or consult an endocrinologist to consider whether to stop or continue taking the medication after weighing the pros and cons. In case of diarrhea on metformin, it will usually be relieved naturally after stopping the drug. If the diarrhea is more obvious, you can also prepare your own probiotic oral treatment, such as oral Clostridium typhimurium tablets, or Bacillus coagulans, etc. You need to check the drug instructions in detail or consult the clinical pharmacist for the specific medication. When patients have diarrhea, they should pay attention to the diet with a light diet, eat less and more meals, do not eat cold, sour and spicy food, and do not smoke, do not drink, and also pay attention to the abdominal warmth.