Chronic hepatitis B is a progressive disease caused by the hepatitis B virus (HBV). Without effective treatment, about 20% to 40% of chronic hepatitis B patients will develop cirrhosis, and a significant proportion will progress to decompensated cirrhosis, posing a threat to life; another proportion of patients follow the so-called “hepatitis-cirrhosis-liver cancer” trilogy and eventually progress to liver cancer. From the beginning of hepatitis B treatment, we should consider how to choose drugs and how to fight the virus. The only way to significantly reduce hepatitis B cancer is to achieve a higher goal. I have observed hepatitis B cases for a long time and have also done prospective cohort studies and found that for reducing hepatitis B carcinogenesis and preventing liver cancer, the most effective measure is still tertiary prevention, which can reduce the incidence of liver cancer to the lowest level and, if practiced consistently, is almost cancer-free. However, I believe that it is too late to get to the third level, and all prevention must be done at the second level to prevent the disease before it happens. I have observed cases where primary and secondary prevention measures were taken early and did not progress to liver cancer. Don’t wait.