Penicillin treatment for syphilis is usually administered by intramuscular injection, usually once a week, for a total of 3-4 injections. However, the exact duration of treatment varies from person to person and is subject to regular review to determine whether syphilis has been eradicated. Syphilis is a sexually transmitted disease caused by infection with the syphilis spirochete, and penicillin is the treatment protocol recommended by the State Ministry of Health for the treatment of syphilis in its early stages with remarkable results. In general, penicillin intramuscular injection once a week, a total of 3-4 times can be effective, provided that the patient is not allergic to penicillin, and need to go to the regular hospital dermatological venereal disease department for diagnosis, injection. In the case of second-stage syphilis, a combination of other means of comprehensive treatment is required. In addition, it is recommended that patients be reviewed regularly after treatment is completed, every three months in the first year and every six months in the second year, to prevent recurrence. Patients need to avoid sexual intercourse as much as possible during the treatment period, pay attention to the regularity of daily life, eat a light diet, avoid spicy and stimulating diet, avoid smoking and alcohol.