The toxicity of epiphyllum is affected by a variety of factors such as the origin of the herb, concoction and processing methods, water decoction time, has a large difference, the specific how many grams will be poisoned and there is no exact value, the general clinical dosage of 3 to 15g, but also should be decocted first, for a long time, in order to reduce the toxicity. The drug source of epiphyllum is the processed product of the cotyledon of Aconite, family Buttercupaceae, which is pungent, sweet, hot and poisonous in nature. It has the efficacy of returning yang to save the body (rescuing fainting, unconsciousness, etc. by warming yang qi), tonifying fire to help yang (replenishing the body’s yang qi), and dispersing cold and relieving pain (relieving pain by dispelling the body’s cold evil). It can be used in the treatment of yang deficiency, chest paralysis (chest pain), heart pain, cold vomiting and diarrhea, epigastric cold pain (cold pain in the stomach and abdomen), impotence, uterine cold and cold-dampness paralysis and pain, etc. The general dosage is 3-15g, which is a safer dosage range. It is forbidden to take it in cases of deficiency of Yin and Yang, true heat and false cold, and in pregnant women. In addition, pregnant women should be cautious of the use of epiphyllum, and epiphyllum should not be used with half-summer, piper betel, smallpox pollen, shellfish, Ampelopsis, white and other Chinese herbs, which is toxic, the specific use of the physician’s diagnosis should be guided.