This disease, also known as pseudogout or articular cartilage calcification, is rare, and Zitnan and Sitai (1960) described a syndrome of calcification of articular cartilage with gout-like symptoms as articular cartilage calcification. Articular cartilage calcification is characterized by the deposition of calcium salts in the glassy cartilage and fibrocartilage of one or more joints. McCarty and Gatter (1963) identified calcium pyrophosphate crystals in the joint fluid of patients with acute arthritis associated with calcification of articular cartilage, which is called pseudogout because of its acute and chronic symptoms resembling gouty arthritis. 1, etiology The etiology of this disease is unknown, often associated with trauma (including surgery), amyloidosis, mucinous edema, hyperparathyroidism, gout and hemochromatosis. It is suggested that the deposition of calcium dihydroxypyrophosphate (PPD) crystals in cartilage is secondary to degenerative or metabolic changes in cartilage. 2, clinical manifestations and differentiation The age of onset is more than 40 years old, and there is no significant difference between men and women. The disease starts suddenly with an acute attack, the joints are red, swollen, hot and painful, and there is often fluid in the joint cavity. It occurs most often in the knee and other common joints such as the hip, ankle, shoulder, elbow and wrist, and occasionally in small joints, but rarely in the first metatarsophalangeal joint of the foot as in gout. It is often an acute attack in a single joint. It can be triggered by surgery and trauma. The chronic form may invade multiple joints, is symmetrical, and progresses slowly, similar to osteoarthritis. The clinical manifestations of pseudogout are similar to those of gout, but are milder and less likely to involve the small joints of the extremities, where gout tends to occur. In acute attacks, the blood sedimentation increases rapidly, the white blood cells increase, and the blood uric acid value is not high. Calcium pyrophosphate dihydrate crystals can be found in the synovial fluid of the joints. Dotted and linear calcified spots of articular cartilage can be seen on X-rays. Treatment Treatment can usually stop acute attacks and prevent new attacks, but is not effective in stopping the destruction of the affected joint. Non-steroidal anti-inflammatory drugs such as ibuprofen can relieve pain and inflammation. Colchicine is occasionally administered intravenously to reduce symptoms during attacks and to prevent new attacks by taking small daily doses orally. Excessive joint fluid may be aspirated by arthrocentesis and injected with a hormonal suspension to relieve inflammation. There are no specific long-term medications to completely eliminate the crystals deposited in the joint.