Causes of chronic viral hepatitis B peripheral hematopoiesis: 1, hypersplenism: spleen on RBC, WBC, PLT retention and destruction of increased; 2, bone marrow inhibition: HBV can directly damage the bone marrow hematopoietic hepatocytes, virus-mediated autoimmune abnormality of the hematopoietic cells to produce inhibition of the body immune dysfunction, endotoxemia and other endotoxicity in severe liver disease can inhibit bone marrow hematopoietic function; 3, chronic liver disease, thrombocytopenia level, platelet count decreased; 4, poor digestion and absorption, lack of hematopoietic substances, and severe liver disease platelet consumption increased and bleeding, etc.. Hematopoietic function of bone marrow can be inhibited by immune dysfunction and endotoxemia in severe liver disease; 3. Decrease in the level of thrombopoietin and reduction in the number of platelets in chronic liver disease; 4. Poor digestion and absorption, lack of hematopoietic substances, and increased consumption of platelets in severe liver disease and bleeding.